April 26 Highlight and Commentary: Disorders of cobalamin metabolism

Package ‘ signeR ’ April 26 , 2017

April 26, 2017 Type Package Title Empirical Bayesian approach to mutational signature discovery Version 1.2.0 Author Rafael Rosales, Rodrigo Drummond, Renan Valieris, Israel Tojal da Silva Maintainer Renan Valieris Description The signeR package provides an empirical Bayesian approach to mutational signature discovery. It is designed to analyze single nucl...

Access published April 26 , 2007

Package ‘ paircompviz ’ April 26 , 2017

April 26, 2017 Type Package Title Multiple comparison test visualization Version 1.14.0 Date 2013-06-01 Author Michal Burda Maintainer Michal Burda Description This package provides visualization of the results from the multiple (i.e. pairwise) comparison tests such as pairwise.t.test, pairwise.prop.test or pairwise.wilcox.test. The groups being compared are visualized as ...

PASPCR Commentary, April 2006

How did you begin working in this area? I got my first permanent job, following my post doc, as a bench scientist with the skin biology group of the Pharmaceutical Research Institute of Johnson & Johnson. I was involved in basic research of hair growth and epidermal differentiation. We found that a delicate balance of endogenous serine proteases and their inhibitors is essential for skin homeos...

Disorders of cobalamin (vitamin B12) metabolism: emerging concepts in pathophysiology, diagnosis and treatment.

Although cobalamin (vitamin B12) was isolated almost 60 years ago, its biochemical, physiologic and neurologic effects remain incompletely defined. New observations suggest renal regulation of cobalamin metabolism; actions of cobalamin on nucleic acid and protein function; and a role for cobalamin in cytokine and growth factor regulation. Clinically, no gold standard has emerged for the diagnos...